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Cepheid
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September, 11 2024
ANTIMICROBIAL STEWARDSHIP
Impact Story
PCR Screening at a British Hospital Enables Timely Infection Control
At Royal Liverpool and Broadgreen University Hospitals NHS, the turnaround time for carbapenemase-producing enterobacterales (CPE) testing using culture and phenotypic confirmation was up to 72 hours.
Because there was a lack of rooms to isolate the patients at the hospital, patients could be released before their test results were available.
This delay increased the risk of the spread of CPE, resulting in the loss of beds and ward closures to prevent further spread of CPE. Il costo per l’occupazione extra di ogni singolo letto era di 200 sterline al giorno, con importi pari a 150.000 sterline se un reparto con 25 letti era costretto a chiudere per un mese.
L’ospedale necessitava fortemente l’implementazione di un metodo di screening più rapido per CPE al fine di eliminare la possibilità che i pazienti diffondessero i batteri o fossero dimessi prima di ricevere i risultati del test.
In order to avoid delays and prevent the spread of CPE, the Royal Liverpool and Broadgreen University Hospitals NHS Trust implemented PCR-based CPE testing using the Xpert® Carba-R test on a GeneXpert® Infinity system to enable faster screening. The Xpert Carba-R test provides results in 50 minutes, significantly reducing the total turnaround time (TAT) from 72 hours to 4 hours.
The expedited TAT allowed room bays to be decanted and decontaminated quickly, reducing the number of beds lost to CPE due to contamination measures by 50%.
“L’introduzione di test molecolari rapidi per il rilevamento degli enterobatteri produttori di carbapenemasi ci ha consentito di ridurre il tempo di refertazione a poche ore anziché giorni, identificare i pazienti colonizzati e adottare le precauzioni necessarie rapidamente”.
-- Dr. Tim Neal, Mersey Programme Director Microbiology, Department of Microbiology Royal Liverpool University Hospital, Royal Liverpool and Broadgreen University Hospitals NHS Trust
Listen to Dr. Tim Neal, Mersey Programme Director Microbiology, Department of Microbiology Royal Liverpool University Hospital, Royal Liverpool and Broadgreen University Hospitals NHS Trust discuss infection control within his organizations.
Learn more about PCR-based CPE testing using the Xpert® Carba-R test on the GeneXpert® Infinity system to enable effective screening.
CE-IVD. In Vitro Diagnostic Medical Device. Potrebbe non essere disponibile in alcuni Paesi.
*Projections and realized results are specific to the institution where they were obtained and may not reflect the results achievable at other institutions
Riferimento:
Corless, C E et al. “Impact of different carbapenemase-producing Enterobacterales screening strategies in a hospital setting.” Infection prevention in practice vol. 2,3 100011. 21 May. 2020 doi:10.1016/j.infpip.2019.100011
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