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28. April 2025
ATEMWEGSGESUNDHEIT
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Was ist der Unterschied zwischen PCR und Antigentests?
Respiratory viral infections remain a significant cause of healthcare visits worldwide, with the COVID-19 pandemic emphasizing the critical need for timely and accurate diagnostic testing. Testing capabilities have advanced in recent years, and various options exist, differing in accuracy, detection window, viral markers, and use cases.
Polymerase Chain Reaction (PCR) and antigen testing are routine techniques for detecting respiratory viruses such as SARS-CoV-2, influenza, and others. Healthcare providers must stay informed about the capabilities and applications of antigen and PCR tests to maximize diagnostic accuracy and ensure efficient resource utilization for better patient care.
View the infographic below to understand how PCT and antigen tests differ.
Referenzen:
1. ADLM Guidance Document on Laboratory Diagnosis of Respiratory Viruses | myadlm.org. Zugriff am 27. August 2024. https://www.myadlm.org/Science-and-Research/Academy-Guidance/Laboratory-Diagnosis-of-Respiratory-Viruses
2. Hanson KE, Azar MM, Banerjee R, et al. Molecular testing for acute respiratory tract infections: clinical and diagnostic recommendations from the idsa’s diagnostics committee. Clin Infect Dis. 2020;71(10):2744-2751. doi:10:1093/cid/ciaa508
3. Rapid Influenza Diagnostic Tests | Influenza (Flu) | CDC. Zugriff am 06. Januar 2025. https://www.cdc.gov/flu/hcp/testing-methods/clinician_guidance_ridt.html?CDC_AAref_Val=https://www.cdc.gov/flu/professionals/diagnosis/clinician_guidance_ridt.htm
4. Dinnes J, Sharma P, Berhane S, et al. Rapid, point-of-care antigen tests for diagnosis of SARS-CoV-2 infection. Cochrane Database Syst Rev. 2022;7(7):CD013705. doi:10:1002/14651858.CD013705.pub3
5. Testing for COVID-19 | COVID-19 | CDC. Zugriff am 28. August 2024. https://www.cdc.gov/covid/testing/index.html
6. https://www.fda.gov/medical-devices/safety-communications/home-covid-19-antigen-tests-take-steps-reduce-your-risk-false-negative-results-fda-safety. Zugriff am 28. August 2024. https://www.fda.gov/medical-devices/safety-communications/home-covid-19-antigen-tests-take-steps-reduce-your-risk-false-negative-results-fda-safety
7. Algorithm to assist in the interpretation of influenza testing results and clinical decision-making during periods when influenza viruses are circulating in the community | CDC. Zugriff am 27. August 2024. https://www.cdc.gov/flu/professionals/diagnosis/algorithm-results-circulating.htm
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10. Charlton CL, Babady E, Ginocchio CC, et al. Practical guidance for clinical microbiology laboratories: viruses causing acute respiratory tract infections. Clin Microbiol Rev. 2019;32(1). doi:10:1128/CMR.00042-18
11. Davies S, Boller E, Chase J, Beaubrun A, Miller C, Jensen I. A cost-consequence analysis of the Xpert Xpress CoV-2/Flu/RSV plus test strategy for the diagnosis of influenza-like illnesses. J Med Econ. 2024;27(1):430-441. doi:10:1080/13696998:2024:2313391
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